Parkinson’s, Dystonia & Movement Disorders

Select a condition to begin searching our available clinical trials and research studies.

Ataxia

Friedreich’s Ataxia

Natural History of Friedreich’s Ataxia in Children

This study aims to advance clinical care, research and therapeutic approaches in Friedreich’s ataxia (FA) through the development and validation of clinical outcome measures in FRDA, collection of quantitative serial clinical data on patients and expansion of our established research network.

FRIEDREICH’S ATAXIA

Collaborative Clinical Research Network in Friedreich’s Ataxia

To advance clinical care, research and therapeutic approaches in Friedreich’s ataxia (FA) through the development and validation of clinical outcome measures in FA, collection of quantitative serial clinical data on patients and expansion of our established research network.

FRIEDREICH’S ATAXIA

Biomarkers in Friedreich’s Ataxia

The purpose of this research study is to find out what the best tests and evaluations are for measuring the effects of Friedreich’s ataxia on the body, to help us to design clinical trials.

FRIEDREICH’S ATAXIA

A Phase 2 Study of the Safety, Efficacy, and Pharmacodynamics of RTA 408 in the Treatment of Friedreich’s Ataxia – Part 2 and Extension

This 2-part study will evaluate the efficacy, safety, and pharmacodynamics of omaveloxolone (RTA 408) in the treatment of patients with Friedreich’s ataxia.

Spinocerebellar Ataxia

A Phase III, Long-Term, Randomized, Double-blind, Placebo-controlled Trial of Troriluzole in Adult Subjects with Spinocerebellar Ataxia

The purpose of this study is to compare the efficacy of Troriluzole (200mg once daily) versus placebo after 48 weeks of treatment in subjects with spinocerebellar ataxia (SCA).

SPINOCEREBELLAR ATAXIA

Clinical Trial Readiness for SCA1 and SCA3

The investigators plan to fill the gap between the current state of clinical trial readiness and the optimal one for SCA1 and SCA3, which are fatal rare diseases with no treatments.

SPINOCEREBELLAR ATAXIA

Clinical Research Consortium for Spinocerebellar Ataxias (CRC-SCA) to Study Natural History and Genetic Modifiers in Spinocerebellar Ataxia (SCA)

The purpose of this research study is to bring together a group of experts in the field of SCA for the purpose of learning more about the disease.

Spinocerebellar Ataxia

A Phase IIb/III, Randomized, Double-blind, Placebo-controlled Trial of BHV-4157 in Adult Subjects with Spinocerebellar Ataxia

he primary purpose of this study is to compare the efficacy of BHV-4157 versus placebo after 8 weeks of treatment on ataxia symptoms in subjects with spinocerebellar ataxia (SCA).

Dystonia

Dystonia

(ASPEN-1) A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Multi-Center Trial to Evaluate the Efficacy and Safety of a Single Treatment of DaxibotulinumtoxinA for Injection in Adults with Isolated Cervical Dystonia

Researchers want to find out if daxibotulinumtoxinA for injection, a new investigational study drug, is safe and effective for use in adults with isolated cervical dystonia (CD) and if the effects last longer than the standard toxin treatment.

Huntington’s Disease

Enroll-HD

The purpose of this research study is to collect clinical information about you and your health. We will also collect biological samples, such as blood and DNA (the genetic material in your blood). Researchers will use this information and samples to learn more about Huntington’s disease and to try to find new treatments for the disease

Parkinson’s Disease

Parkinson’s Disease

A Proof of Concept Study to Investigate the Effect of IPT803 Adjunct Treatment in Patients with Parkinson’s Disease

The purpose of this study is to learn more about the effects of treatment with IPT803 on Parkinson’s disease symptoms and how it impacts your daily life.

PARKINSON’S DISEASE

Dopamine transmission in peripheral immune cells of patients with Parkinson’s disease

The purpose of this research is to collect blood from Parkinson’s disease patients and healthy individuals, as well as patients with major depressive disorder and Alzheimer’s disease, of the same age or gender as those patients in the hope to find future diagnostics tools and establish early therapeutic biomarkers for Parkinson’s disease.

PARKINSON’S DISEASE

Dietary intervention and gastrointestinal function in patients with Parkinson’s disease

This study determines a baseline for leaky gut for people with Parkinson’s disease (PD) versus healthy controls. We also hope to see if eating a Mediterranean diet will alter gut, bacteria, inflammation, and function in people with PD.

PARKINSON’S DISEASE

Parkinson’s Outcome Project

The purpose of this research study is to collect data on individuals with Parkinson disease to better understand the illness and ultimately improve the care and survival of those individuals with the disease.

PARKINSON’S DISEASE

A Pilot Intervention with Near Infrared Stimulation: Revitalizing Cognition in Older Adults

We are recruiting individuals with Parkinson disease for a new brain stimulation study that involves ‘shining’ light on the brain.

PARKINSON’S DISEASE

Image Parkinson’s disease Progression Study

The purpose of this research study is to investigate how the brain and motor behavior changes Parkinson’s disease over time in response to rasagiline and to investigate new methods of evaluating non-invasive MRI-based biomarkers of PD progression in the brain.

PARKINSON’S DISEASE

Longitudinal Parkinson’s Research Study

The purpose of this research study is to investigate how the brain and motor behavior changes both in individuals with movement disorders and healthy individuals over time.

PARKINSON’S DISEASE

Cross-validation of the Comprehensive Older Adults Screening Tool (COAST) in patients with Parkinson’s disease

The purpose of this study is to validate a malnutrition screening tool in patients with Parkinson’s disease.

PARKINSON’S DISEASE

Physiological Flow of Liquids Used in Dysphagia Management

This study will help us to better understand swallowing impairment and how liquid thickness influences swallowing function.

PARKINSON’S DISEASE

Validating PD Cognitive Profiles. Substudy: White Matter Connectivity and PD Cognitive Phenotypes

The purpose of this research study is to investigate 1) brain and blood markers of memory and thinking difficulties in Parkinson’s disease, and 2) how these markers can predict different memory and thinking difficulties over a period of two years. Individuals diagnosed with Parkinson’s disease are being compared to individuals who do not have Parkinson’s disease.

PARKINSON’S DISEASE

Improving Detection and Clinical Care of Dysphagia in Cardiac Surgical Patients

The purpose of this research is to improve the identification of patients who are at greater risk for development of dysphagia (dys FAY juh – swallowing difficulties) after cardiac surgery.

PARKINSON’S DISEASE

CODY Testing 1

The purpose of this research is to assess how useful a Virtual Reality program is in assisting and enhancing the ability of adults to experience and choose appropriate home modifications for themselves.

PARKINSON’S DISEASE

(The PRESENCE Study) Effect of LY3154207 on Cognition in Mild-to-Moderate Dementia Due to Lewy Body Dementia (LBD) Associated with Idiopathic Parkinson’s Disease (PD) or Dementia with Lewy Bodies (DLB)

The purpose of this additional research study is to determine whether LY3154207 has an effect on your blood pressure and pulse rate during normal activities, especially while you are asleep at night.

PARKINSON’S DISEASE

National DBS Brain Tissue Network

The goal of this study is to store your tissues and medical information and potentially use it in future research.

PARKINSON’S DISEASE

Investigation of Microbiota changes in patients with DBS

The purpose of this research study is to determine the effects of Deep Brain Stimulation (DBS) on gut health in patients with Pakinson’s disease (PD) and without Parkinson’s disease (this is the control group).

PARKINSON’S DISEASE

Mechanisms of airway protection dysfunction in Parkinson’s disease

The purpose of this research study is to determine the reasons why people with Parkinson’s disease (PD) develop problems swallowing and coughing, and how they change with disease progression.

Tourette Syndrome

Tourette Syndrome

A Well-Controlled, Fixed-Dose Study of TEV-50717 (Deutetrabenazine) for the Treatment of Tics Associated with Tourette Syndrome

If your child (ages 6-16) have been diagnosed with Tourette syndrome you may be eligible to take part in a research study of an experimental drug called TEV-50717, which is being developed as a treatment for tics associated with Tourette syndrome in children and adolescents.

Tourette Syndrome

Physiologic Approach to Human Tics – Tic Detector

The purpose of this research study is to determine if we can use muscle activity to detect tics involving the arms, legs and back.

Tourette Syndrome

Handwriting deficits in children with tic disorders or Tourette syndrome

The purpose of this research study is to better understand if there are handwriting changes and patterns associated with Tourette syndrome and tic disorders.

TOURETTE SYNDROME

Southeast Centers Tic Disorders Data Bank

We wish to store your medical information and routine completed questionnaires to potentially use it in future research. Many different kinds of research uses medical information from data bank sources.

TOURETTE SYNDROME

Tourette Syndrome Deep Brain Stimulation

The purpose of this study is to learn how deep brain stimulation affects motor and vocal tics associated with severe Tourette Syndrome that is not adequately controlled with medication.

Tremors

ESSential tremor

Closing the Loop on Tremor: A Responsive Deep Brain Stimulator for the Treatment of Essential Tremor

ESSENTIAL TREMOR

Dual Lead Thalamic DBR-DBS Interface for Closed Loop Control of Severe Essential Tremor