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The primary objective of this study is to investigate the safety and clinical effect of a continuous low-dose intravenous unfractionated heparin (LDIVH) infusion for the prevention of aneurysmal subarachnoid hemorrhage (aSAH) induced neurocognitive dysfunction and other delayed neurological deficits.
The objective of this study is to obtain “real world” clinical data and characterize the acute and long-term performance of the MICRUSFRAME and GALAXY coils for the endovascular treatment of intracranial aneurysms.
The purpose of this study is to compare angiographic outcomes in patients receiving 0.014-0.0155″ platinum framing and filling coils (larger diameter coils) versus those treated solely with coils less than 0.014″ (with a standard diameter).
The purpose of this research study is to collect data from patients with small cerebral aneurysm that are treated with Stryker “Nano Coils” and to compare information on the safety and effectiveness of treating small aneurysms (e.g., those that are less than 4 mm in size) to information we have on treatment of larger aneurysms.
The purpose of this research study is to determine if an investigational dendritic cell vaccine, called pp65 DC, is effective for the treatment of a specific type of brain tumor called The purpose of this research study is to determine if an investigational dendritic cell vaccine, called pp65 DC, is effective for the treatment of a specific type of brain tumor called glioblastoma (GBM) when given with stronger doses of routine chemotherapy. (GBM) when given with stronger doses of routine chemotherapy.
In this research study, we will use a patient’s tumor to make a vaccine which we hope will stimulate T-cells to kill tumor cells and leave normal cells alone.
Patients in this study will either receive concurrent TMZ during RT and immunotherapy during and after maintenance cycles of dose-intensive TMZ (Group A) or focal radiotherapy alone and immunotherapy without maintenance DI TMZ (Group B). Immune responses during cycles of DC vaccination with or without DI TMZ will be evaluated in both treatment groups.
The main goal of this efficacy study is to learn how well tozuleristide and the Canvas work at detecting tumors during surgery. This study will also look at the safety of using tozuleristide and the Canvas for surgery.
The purpose of this study is to see if there are any differences between patients who receive Levetiracetam extended-release tablets for one week after surgery to remove a brain tumor versus those who receive Levetiracetam extended-release tablets for six weeks after surgery.
The purpose of this research study is to determine if treatment with Optune during maintenance cycles of Temozolomide is effective in the treatment of Grade II or III astrocytoma brain tumor(s).
The purpose of this research study is to collect information on how people respond to treatment with Optune and to see if their response to treatment relates to the genetic make-up of their tumor.
This research study is being performed to determine whether or not TTFields combined with pulsed bevacizumab treatment increases overall survival in patients with bevacizumab-refractory GBM compared to historical controls treated with continuous bevacizumab alone or in combination with other chemotherapy.
This study is being performed to determine whether the triple combination of pembrolizumab when added to TTFields (Optune®) and adjuvant temozolomide increases progression-free survival (PFS) in patients with newly diagnosed GBM as compared to historical control data.
This study will look to determine the safety and recommended phase 2 dose of the modified measles virus (MV-NIS) in children and young adults with recurrent medulloblastoma or atypical teratoid rhabdoid tumor (ATRT).
This research study will compare two different treatment regimens to see which is better for treating children with different types of brain tumors called medulloblastoma and CNS embryonal tumors of the brain or spinal cord.