Neurosurgery

Select a condition to begin searching our available clinical trials and research studies.

Cerebrovascular

Subarachnoid Hemorrhage

(ASTROH) Aneurysmal Subarachnoid Hemorrhage Trial Randomizing Heparin: A Prospective, Randomized, Phase IIA Pilot Study of Unfractionated Heparin in aSAH

The primary objective of this study is to investigate the safety and clinical effect of a continuous low-dose intravenous unfractionated heparin (LDIVH) infusion for the prevention of aneurysmal subarachnoid hemorrhage (aSAH) induced neurocognitive dysfunction and other delayed neurological deficits.

Intracranial saccular aneurysm

(CNV_2017_01) A Prospective, Multi-Center, Single Arm Study to obtain “real world” clinical data and characterize the acute and long-term performance of the MICRUSFRAME and GALAXY coils including the PulseRider Aneurysm Neck Reconstruction device for the endovascular treatment of intracranial aneurysms

The objective of this study is to obtain “real world” clinical data and characterize the acute and long-term performance of the MICRUSFRAME and GALAXY coils for the endovascular treatment of intracranial aneurysms.

Intracranial Aneurysm

(FEAT) Framing Eighteen coils in cerebral Aneurysms

The purpose of this study is to compare angiographic outcomes in patients receiving 0.014-0.0155″ platinum framing and filling coils (larger diameter coils) versus those treated solely with coils less than 0.014″ (with a standard diameter).

INTRACRANIAL ANEURYSM

(NANO) Effectiveness and Safety of Small Aneurysm Coiling Trial

The purpose of this research study is to collect data from patients with small cerebral aneurysm that are treated with Stryker “Nano Coils” and to compare information on the safety and effectiveness of treating small aneurysms (e.g., those that are less than 4 mm in size) to information we have on treatment of larger aneurysms.

Brain Tumor

Glioblastoma

(ATTAC-II) A Phase II Randomized, Blinded, and Placebo-controlled Trial of CMV RNA-Pulsed Dendritic Cells with Tetanus-Diphtheria Toxoid Vaccine in Patients with Newly-Diagnosed Glioblastoma

The purpose of this research study is to determine if an investigational dendritic cell vaccine, called pp65 DC, is effective for the treatment of a specific type of brain tumor called The purpose of this research study is to determine if an investigational dendritic cell vaccine, called pp65 DC, is effective for the treatment of a specific type of brain tumor called glioblastoma (GBM) when given with stronger doses of routine chemotherapy. (GBM) when given with stronger doses of routine chemotherapy.

WHO Grade III or IV malignant glioma

(ACTION) Adoptive Cellular Therapy following Dose-Intensified Temozolomide in Newly-diagnosed Pediatric High-grade Gliomas

In this research study, we will use a patient’s tumor to make a vaccine which we hope will stimulate T-cells to kill tumor cells and leave normal cells alone.

Pediatric brain tumor

(BRAVO) Newly-Diagnosed Brain Stem Gliomas Treated with Adoptive Cellular Therapy during Recovery from Focal Radiotherapy Alone or Radiotherapy and Dose-intensified Temozolomide

Patients in this study will either receive concurrent TMZ during RT and immunotherapy during and after maintenance cycles of dose-intensive TMZ (Group A) or focal radiotherapy alone and immunotherapy without maintenance DI TMZ (Group B). Immune responses during cycles of DC vaccination with or without DI TMZ will be evaluated in both treatment groups.

CNS Tumor

A Randomized, Blinded Study of Fluorescence Detection of Pediatric Primary Central Nervous System Tumors in Subjects Receiving Tozuleristide and Imaged with the Canvas System

The main goal of this efficacy study is to learn how well tozuleristide and the Canvas work at detecting tumors during surgery. This study will also look at the safety of using tozuleristide and the Canvas for surgery.

CNS Tumor

(Keppra Study) A Shortened Antiepileptic Drug (AED) Course in Surgical Brain Tumor Patients: A Randomized Trial

The purpose of this study is to see if there are any differences between patients who receive Levetiracetam extended-release tablets for one week after surgery to remove a brain tumor versus those who receive Levetiracetam extended-release tablets for six weeks after surgery.

Grade II or III astrocytoma brain tumor

(FORWARD) A Phase 2, Historically Controlled Study Testing the Efficacy of TTFields (Optune®) With Adjuvant Temozolomide in High Risk WHO Grade II and III Astrocytomas

The purpose of this research study is to determine if treatment with Optune during maintenance cycles of Temozolomide is effective in the treatment of Grade II or III astrocytoma brain tumor(s).

Recurrent Glioblastoma Multiforme (GBM)

(PRECISION) A Phase II Study of the Optune System, Enhanced by Genomic Analysis to Identify the Genetic Signature of Response in the Treatment of Recurrent Glioblastoma Multiforme

The purpose of this research study is to collect information on how people respond to treatment with Optune and to see if their response to treatment relates to the genetic make-up of their tumor.

Recurrent Glioblastoma Multiforme (GBM)

(PULSED AVASTIN) A Phase 2, Multi-center, Single arm, Histologically Controlled Study Testing the Combination of TTFields and Pulsed Bevacizumab Treatment in Patients with Bevacizumab-refractory Recurrent Glioblastoma

This research study is being performed to determine whether or not TTFields combined with pulsed bevacizumab treatment increases overall survival in patients with bevacizumab-refractory GBM compared to historical controls treated with continuous bevacizumab alone or in combination with other chemotherapy.

Newly diagnosed Glioblastoma Multiforme (GBM)

(2-THE-TOP) Phase 2, Single Arm, Historically Controlled Study Testing The Safety and Efficacy of Adjuvant Temozolomide Plus TTFields (Optune®) Plus Pembrolizumab in Patients with Newly Diagnosed Glioblastoma

This study is being performed to determine whether the triple combination of pembrolizumab when added to TTFields (Optune®) and adjuvant temozolomide increases progression-free survival (PFS) in patients with newly diagnosed GBM as compared to historical control data.

Medulloblastoma

(PNOC-005) A Phase 1 Study of Modified Measles Virus (MV-NIS) for the Treatment of Children and Young Adults with Recurrent Medulloblastoma or Recurrent Atypical Teratoid Rhabdoid Tumors (ATRT)

This study will look to determine the safety and recommended phase 2 dose of the modified measles virus (MV-NIS) in children and young adults with recurrent medulloblastoma or atypical teratoid rhabdoid tumor (ATRT).

pediatric brain tumor

(HeadStart 4) Newly Diagnosed Children (Less than 10 Years Old) With Medulloblastoma and Other Central Nervous System Primitive Neuro-Ectodermal Tumors: Clinical and Molecular Risk-Tailored Intensive and Compressed Induction Chemotherapy Followed by Consolidation with Either Single-Cycle (Low Risk Patients) or Randomization (High Risk Patients) to either Single-Cycle or to Three Tandem Cycles of Marrow-Ablative Chemotherapy with Autologous Hematopoietic Progenitor Cell Rescue

This research study will compare two different treatment regimens to see which is better for treating children with different types of brain tumors called medulloblastoma and CNS embryonal tumors of the brain or spinal cord.

high-grade glioma

PNOC 008: A Pilot Trial Testing the Clinical Benefit of Using Molecular Profiling to Determine an Individualized Treatment Plan in Children and Young Adults with High Grade Glioma (Excluding Diffuse Intrinsic Pontine Glioma)

The main purpose of this study is to find out if personalized cancer medicine can treat or stop high-grade glioma (HGG) from getting worse.